Revaree vs Estradiol: Which is Better for Vaginal Dryness?

Should you use Estradiol or Revaree for vaginal dryness? As a woman in perimenopause, I want to share my thoughts.

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Is vaginal dryness negatively impacting your sex life? Is it making you uncomfortable throughout the course of the day? I’m here to tell you that there is safe, natural and effective relief available. Rather than turning to chemical-based lubricants that only last temporarily and disrupt the natural balance of your vaginal flora, let’s consider Revaree versus Estradiol. Are you ready for all the details of these two products? Let’s get started!

Key Factors to Know: Revaree vs. Estradiol

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  • The main ingredient in Revaree is hyaluronic acid. Its purpose is to help your body retain moisture naturally.
  • Revaree features a mess-free application design.
  • Revaree from Bonafide is backed by over 7,200 doctors.

Estradiol (We recommend Interlude)

  • Estradiol is a form of estrogen that is created by the ovaries. It can be found in products from companies such as Interlude, Evernow and Alloy.
  • Estradiol is the primary form of estrogen that is produced by the body during the reproductive years.
  • You can use Estradiol for vaginal dryness but other menopause-related symptoms as well.

What is Revaree?

revaree vaginal moisturizer

Revaree by Bonafide is designed to support optimal vaginal health by enhancing lubrication. This can equate to more comfort during sex, reduced irritation and fewer yeast infections. Many women experience vaginal dryness in their 40s and 50s, around the time of perimenopause and menopause. Hyaluronic acid is the active ingredient, which helps the body retain more moisture naturally.

Revaree is slightly different from other vaginal moisturizers on the market because it only has to be used every few days. Inserted into the vagina, it works in a couple of weeks. Most women see its full potential in a few months.

What Are the Side Effects of Revaree?

No serious adverse effects have been reported while using Revaree. It is an FDA-approved product that has been safely used by over one million women.

My Experience

What I liked initially about Revaree is that it was made with a safe, all-natural ingredient that I know is in a number of the beauty products that I use. It wasn’t going to mess with my hormones or disrupt my vaginal flora. Also, it was convenient that I would only need to use Revaree every two to three days.

I first tried Revaree after a bout of vaginal dryness and irritation that I was experiencing. This had been occurring more and more frequently. I didn’t notice much of a difference after the first or second treatment (used three days apart). However, by the second week of using Revaree, I was much more comfortable.


  • Made with hyaluronic acid, which is very safe and natural.
  • You don’t have to use this product every single day.
  • It’s designed to be mess-free.
  • Revaree is FDA-approved.


  • It’s a bit expensive, but you save a bit of money by not using it every single day.
  • If you’re sensitive to hyaluronic acid, this product might not be for you.

What Is Estradiol?

estradiol vaginal cream

Estradiol is a form of estrogen that is produced in the ovaries. It has several functions in the female body, such as maintaining the reproductive system. Estradiol levels rise and fall over the course of your cycle, resulting in the maturation and release of an egg each month. Estradiol also results in the uterine lining thickening.

Estradiol is often used in supplements and products to help treat estrogen deficiency and various symptoms like vaginal dryness, night sweats, hot flashes, mood swings and more.

What Are the Side Effects of Estradiol?

Because estradiol is hormone-based, side effects can occur. If you’re using a topical product versus something taken orally, you may see fewer issues. However, estradiol can cause stomach upset, bloating, headaches and weight gain. Some products may cause irritation.

Who Offers Estradiol?

Estradiol is the main ingredient in a number of products, such as Interlude, Evernow and Alloy.


This is an estradiol-based cream that can be used to treat and prevent symptoms like vaginal dryness, itching, burning and recurring urinary tract infections. I have used Interlude's estradiol vaginal cream in the past with success. However, I needed something that I felt comfortable using on a more long-term basis.

You can purchase Interlude as long as you secure a prescription from the Get Interlude medical team.

Use code FHR1 at checkout for 20% off at Interlude!


Evernow offers an oral estradiol supplement as well as different types of creams and patches. If you’re looking for relief from vaginal dryness, you’ll probably want to look into their Vaginal Estrogen Cream to start with. It’s a bioidentical product that not only addresses vaginal dryness, but also pain during sex, irritation around the vulvar area, frequent urination and frequent urinary tract infections.


Estradiol Vaginal Cream from Alloy is an FDA-approved, plant-based option that is very gentle and safe. It’s a bit expensive, priced at just under $120 for a 3-month supply, but it covers a lot of menopause-related symptoms. I have friends who have tried it, and they were really happy with the results they experienced.


  • Estradiol covers a number of symptoms in addition to vaginal dryness.
  • Most products contain a low enough dose that you don’t have to worry about risks or side effects.
  • This is one of three kinds of estrogen that your body produces naturally. It’s just addressing the fact that you probably have low levels at this point in your life.
  • Estradiol can address the root cause of your symptoms, rather than acting as a bandage for what you’re experiencing.


  • If you take estradiol orally, it can raise your risk of things like blood clots, strokes and heart attack.
  • The cost is usually higher than for other natural products.
  • You will need a prescription for estradiol.

Use code FHR1 at checkout for 20% off at Interlude!

Comparison Section of Estradiol vs. Revaree

Revaree is quite different from other estradiol-based products. Let’s talk about how they compare.

Comparing Formulas

Revaree is based on a hyaluronic formula that boosts your body’s ability to retain moisture in your vaginal region. You’re not applying any kind of hormone to your body when using Revaree, which is something I personally prefer.

Some women feel they need something stronger to address their vaginal dryness, in addition to things like irritation, pain during sex, etc. In these cases, estradiol may be more effective. You can still find very safe, plant-based options that contain a low dose of estradiol if you want to be cautious.

Comparing Price

The current cost of Revaree is $62 for one box of product. A monthly plan is $47, with the 3-month plan costing $42.

There are a number of estradiol-based products available. You may be able to source something from your doctor using your health insurance coverage. Otherwise, online options are available that provide you with access to a medical team that will approve your prescription from the comfort of your home. Prices vary. As an example, Alloy costs $119 for a 3-month supply.

Many of these products can be paid for using your FSA or HSA account.

Main Differences

Estradiol is a hormone. Your body makes it naturally, but you’re still administering something that’s a bit stronger than a hyaluronic-based product. I personally know that estradiol works very well for a lot of different symptoms associated with perimenopause and menopause, so it’s something you may want to look into if you’re experiencing a number of issues that you want to address. Otherwise, a product like Revaree is very effective for vaginal discomfort and dryness.

Are There Any Similarities?

Administration of Revaree and other estradiol-based creams is similar. Revaree boasts a mess-free application process, which, I will say, is very true. I didn’t have any problem applying their product. Other companies and other products will vary a bit depending on how you apply their product, but you are targeting the vagina directly when you’re using something topical.

Conclusion: Which Is Better for Vaginal Dryness?

I personally enjoyed my experience with Revaree. It got rid of the vaginal dryness that I was dealing with, along with any irritation that I had been experiencing. I felt very comfortable using Bonafide’s product because of the simple formula they use. I didn’t worry about any kind of side effect.

Estradiol is also very effective for vaginal dryness. It’s a product that is beneficial if you have other symptoms that you want to address as well.

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Courtney D'Angelo, MS, RD

Courtney D'Angelo, MS, RD, earned her masters degree in Nutrition and Foods from the University of Georgia. She's a Registered Dietitian at Morrison Healthcare and has a strong passion in helping people improve their wellness!

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